Duodenal pseudomelanosis (pseudomelanosis duodeni): a rare endoscopic finding

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Pseudomelanosis Duodeni

A 55-year-old male with history of coronary artery disease, chronic kidney disease stage 4, diabetes mellitus, uncontrolled hypertension (on multiple antihypertensive medications), and iron deficiency anemia was referred for esophagogastroduodenoscopy (EGD) for evaluation of intractable nausea and vomiting. EGD showed black speckled pigmentation of the duodenal mucosa (Figure 1). Duodenal biops...

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Pseudomelanosis Duodeni of Undetermined Etiology

Pseudomelanosis duodeni is a rare, benign condition of unknown etiology. It is characterized by collection of pigment-laden macrophages in the tips of duodenal villi. The pigment, originally interpreted as melanin, pseudomelanin, lipomelanin or hemosiderin, has now been demonstrated to be mostly ferrous sulfide. There is a strong association with chronic renal failure, arterial hypertension, di...

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Pseudomelanosis duodeni: a short review

Pseudomelanosis duodeni is characterized by the presence of brownish or blackish pigmentation in the duodenal mucosa identified during endoscopy. Although the pathogenesis is uncertain, it was generally believed that it is sequelae of luminal absorption of iron and sulfide chemicals, which is subsequently deposited in the lamina propria. It is often associated with hemodialysis and oral intake ...

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Peppered and rare – Gastric and Duodenal Pseudomelanosis: A case series

Upper Gastrointestinal (GI) pseudomelanosis is an uncommon entity characterized by endoscopic visualization of speckled dark mucosal pigmentation. While described in the rectum and colon, 'melanosis' or more aptly 'pseudomelanosis' is rare in the duodenum and exceedingly rare in the stomach. Five cases of pseudomelanosis were encountered at our department. Four females and one male were diagnos...

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Pseudomelanosis of the stomach and duodenum: an uncommon endoscopic finding

A woman (70-years) with a history of iron deficiency anemia and chronic kidney disease presented with two weeks of abdominal pain. Upper endoscopy demonstrated the gastric and duodenal mucosa was black and speckled consistent with diagnosis of pseudomelanosis. Biopsies showed pigment-laden macrophages in the lamina propria, which stained positive for iron and Masson-Fontana trichrome stain cons...

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ژورنال

عنوان ژورنال: Autopsy and Case Reports

سال: 2011

ISSN: 2236-1960

DOI: 10.4322/acr.2011.015